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Gad Consulting Services Cary, North Carolina CONTRIBUTORS Susanna Abrahms e n - Alami, Astra Zeneca R & D Lund, Lund, Sweden, Oral Extended - Release Formulations James Agalloco, Agalloco & Associates, Belle Mead, New Jersey, Sterile Product Manufacturing Fakhrul Ahsan, Texas Tech University, Amarillo, Texas, Nasal Delivery of Peptide and Nonpeptide Drugs James Akers, Akers Kennedy & Associates, Kansas City, Missouri, Sterile Product Manufacturing Raid G. Selegiline is an irreversible monoamine oxidase inhibitor and has a molecular weight of 187.30. - estradiol (Figure 3 ), arecoline, arecaidine, and vasopressin, than colonic or small intestinal mucosa, or at least as permeable as when compared to human buccal mucosa [46, 47] . ( 2002 ), Macrophages and HIV infection: Therapeutical approaches toward this strategic virus reservoir , Antivir. Ability to control or manipulate at the atomic scale Nanotechnology is therefore essentially about understanding and manipulating materials at the atomic, molecular, and macromolecular level in a way that imparts properties to the material that would otherwise not exist either as individual atoms or as bulk processed macroscopic systems. Carl, Purdue University, West Lafayette, Indiana, Biotechnology - Derived Drug Product Development; Regulatory Considerations in Approval of Follow - On Protein Drug Products Sudhir S. 5.11.8.1 Chemical Penetration Enhancers Many approaches that have been investigated over the last several decades enhance the permeation of compounds across the skin using novel chemical compounds [29] . Lipophilic substances are absorbed through the GENERAL FEATURES OF VAGINAL DRUG DELIVERY 819 820 VAGINAL DRUG DELIVERY intracellular (or transcellular) pathway, whereas hydrophilic substances are absorbed through the intercellular (or paracellular) pathway or across aqueous pores present in the vaginal mucosa [49] . ( 2007 ), Effect of temperature on the state of the self - assembled nanoparticles prepared from an amphiphilic lipid derivative of acyclovir , Coll. The pharmaceutical industry is primarily involved in the application of nanomaterials rather than the discovery and development of new materials, though as this chapter will indicate, there are often areas of overlap between what is a new material and a construct of a novel material.